what is glp 1 medicine GLP-1 Medications for Weight Loss Glucagon-like peptide-1 - Wikipedia

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It was reported that the disordered ratio of G/D cells, which can secrete gastrointestinal hormones gastrin and somatostatin, could lead to gastrointestinal dysfunction in acetic acid induced gastric ulcer model[29]

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These hormonal shifts can create a state called GLP-1 resistance, where the drugs effect is partially overridden by an unbalanced hormonal environment easily